In contemporary interior design, there is an increasing trend towards using foliage plants as a biophilic element to enhance occupants’ well-being. Estimating the transpiration rate of these plants is essential for calculating irrigation needs and designing efficient systems and their operations. It also aids in predicting humidity and latent heat impacts in rooms with extensive greenery. The present study aims to develop methods for estimating the transpiration rate of indoor plants. We calculated the transpiration rates considering the heat balance equations of plants and the indoor environment. The calculation method is only based on actual environmental measurements. The difference between the measured and calculated transpiration rates was approximately 109% under artificial lighting. The method of considering the light-shading ratio derived from the 3D model of the plant demonstrated a higher accuracy in estimating the transpiration rate, with the error reduced to 25%. Our results indicate that considering plant morphology significantly improves the accuracy of transpiration rate estimates, especially in conditions with overlapping leaves.