Hospital buildings use extensive energy for constant heating, cooling, and lighting to maintain thermal comfort and indoor air quality. Therefore, particular attention must be given to the hospital design to reduce energy demands and related greenhouse gas emissions. For this purpose, this study aims to evaluate the impacts of passive design strategies on reducing the energy demand of a hospital building in Türkiye, using LEED v4.1 for Healthcare standards as a design criterion. This research objective is achieved by using a prototype building model provided by the Department of Energy (DOE), simulating five scenarios that employ combinations of various passive design strategies using DesignBuilder, and analyzing the impacts on yearly energy demand for heating and cooling. The final scenario, which involved a combination of different building envelope-related measures, scored a 1.44 kWh/m2 reduction in annual cooling demand. The initial results of this study identify the most effective combinations of passive design techniques. This study provides insights into hospital building design to reduce energy demand. Additionally, this research contributes to the literature and the healthcare sector by demonstrating how passive design strategies can effectively reduce cooling energy demand in hospital buildings. The novelty of this study lies in its focus on filling the gap in existing literature, as no research has investigated the effects of passive design strategies and using LEED v4.1 for Healthcare standards simultaneously. Future work could expand on this study by exploring additional passive design strategies and their combined effects on energy demand in hospital buildings.