This study evaluates the performance of 3D-printed hybrid acoustic panels designed to enhance indoor acoustic environments by combining sound absorption and diffusion. Laboratory experiments conducted in the ZEB living lab measured reverberation time (RT60), revealing improvements in the 500–4000 Hz frequency range, which is critical for speech clarity. The panels were tested using two different assemblies, chosen from ten distinct designs, to assess their acoustic effectiveness. Results showed that the larger assembly achieved an average RT60 reduction of 0.10 s, demonstrating the panels’ capability to enhance sound quality in indoor spaces. Furthermore, field experiments in an office environment indicated positive user perceptions of acoustic comfort and panel aesthetics, although some participants expressed preferences for more vibrant designs and increased panel coverage. These results underscore the panels’ potential as a promising solution for indoor spaces, as they enhance acoustic environments while simultaneously balancing visual integration and functional performance.