Air pollution plays vital roles in determining patterns of climate change which result global warming over multiple scales in time and space, owing to the fact that emissions, dispersion, dilution, chemical transformation, and eventual deposition of air pollutants all can be influenced by meteorological variables such as temperature, humidity, wind speed and direction, rainfall and mixing height. There are number of meteorological factors that elaborate the impact of air pollution on regional and global changing in climate. As a result of climate change; the increase in atmospheric and surface temperatures, rising sea levels, the demolish of ice cover, the intensity of heavy rainfall, landslides, hurricanes, cyclones, and the increasing frequency of tornadoes, etc. are all being observed in different parts of the world. Moreover, due to toxic air pollutants different types of human health malfunction as well plant health disorder reported in different region of the globe. In this book chapter, the author discussed about the air pollution, different sources of air pollution and briefly elaborated the impact of air pollution on climate change and their possible factor that are responsible of increasing global warming and climate change. The author also shortly described the impact of air pollution on different human organ health system. In addition to, briefly elaborated the modern tools techniques such as artificial intelligence (AI), machine learning (ML) and remote sensing and Geographical Information System (GIS) for mitigation and management of air pollution.