In the conditions of digitalization, the influence of the adverse human factor in the production system is minimized, and a person gets the opportunity to engage in creative activities rather than routine ones and work in more comfortable conditions, that is, in parallel with technocentricity, human-centricity is formed in industries. IPU RAS has developed a methodology for modeling the process of technological preparation of flexible production of various products (including automatic machines) in various production conditions, taking into account the probabilities of high-quality technological operations. It is noted that flexible production can be realized only in conditions of digitalization. The proposed methods and algorithms can flexibly adjust to different production conditions and help the technologist decide on the possibility and expediency of putting the product into production. As a further development of this methodology, the relevance of the scientific problem of creating a unified formalized approach to studying the process of organizing human creative work in flexible industries is substantiated. It is shown that one of the components of the formalized description is the probability of the targeted use of working time, which is proposed to be determined using the results of population surveys.