In the rapidly evolving world of human-machine interaction, the ability to translate human thoughts into physical movements is gaining popularity in the area of rehabilitation robotics. This breakthrough marks a significant step forward in assistive technology. At the core of this progress, neuro-motor control is a promising approach that enables individuals with limb impairments to regain lost hand movements and experience a renewed sense of functionality through advanced prosthetic hands. This chapter explores how human intention can be decoded and transformed into physical action for control of a prosthetic hand through advances in neuro-motor control. A deeper understanding of the fundamental principles of neural pathways involved in motor control including the role of motor planning, action initiation and execution will be discussed. Further, this chapter will delve into the recent advances in neuro-motor control using brain-machine interface with the integration of sensory feedback. By synthesizing the current trends in research, this chapter presents the state-of-the-art in neuro-motor control for translating human intentions to prosthetic hand movements for improving the quality of life of individuals with upper limb amputations.