This chapter presents a comprehensive study of intermediate band solar cells (IBSCs) based on quantum wells, focusing on the influence of various physical and technological factors on their photovoltaic performance. The effects of alloy composition, quantum well confinement, size parameters, hydrostatic pressure, as well as applied electric and magnetic fields, are systematically investigated. These factors play a crucial role in modulating the electronic and optical properties of the intermediate band, thereby impacting key device performance metrics such as open-circuit voltage, short-circuit current density, fill factor, and overall conversion efficiency. Understanding these interdependencies is essential for optimizing IBSC designs and advancing the development of high-efficiency solar cells.