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Orodispersible tablets (ODTs) are solid oral dosage forms that rapidly disintegrate in the mouth, offering improved bioavailability and patient compliance. Direct compression is a widely used manufacturing method due to its efficiency and cost-effectiveness. However, attaining an optimal balance between mechanical strength and rapid disintegration remains a challenge. Co-processed excipients (CPEs) enhance tablet properties by improving flowability, compressibility, and disintegration characteristics. This study investigates the effect of different CPEs on the wetting time and water absorption ratio of placebo ODTs produced by direct compression. Six series of placebo ODT, incorporating different CPEs (Hisorad™, Granfiller-D™, SmartEx®, Combilac®, Pearlitol® Flash, and Starlac®) were formulated. The wetting time and water absorption ratio, one of the disintegration performance indicators, were evaluated to determine the impact of CPE composition on ODT properties. The results showed that formulations containing Hisorad™ and Granfiller-D™ exhibited the shortest wetting times (25.07 ± 1.04 s and 14.14 ± 0.12 s, respectively) and the highest water absorption ratios (139.93% and 115.24%), suggesting superior disintegration characteristics. In contrast, Starlac® and Pearlitol® Flash demonstrated longer wetting times (24.14 ± 0.43 s and 21.99 ± 0.13 s) and lower absorption ratios (42.50% and 49.80%), which may be attributed to their composition and higher compression forces used during manufacturing. The conducted study highlight the importance of adequate CPE selection and compression force optimization in developing ODTs with desirable properties. Further pharmaceutical-technological characterization is necessary to fully assess the impact of these factors properties on the final formulation.

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Formulation of Orodispersible Tablets: Investigating the Role of Co-processed Excipients in Wetting Time and Water Absorption Ratio

  • 会议论文

  • 发表日期：

    2026年

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  • Lamija Hindija,
  • Jasmina Hadžiabdić,
  • Ognjenka Rahić,
  • Amina Tucak-Smajić,
  • Merima Šahinović,
  • Amra Demirović,
  • Nera Mujezin,
  • Edina Vranić

摘要

Orodispersible tablets (ODTs) are solid oral dosage forms that rapidly disintegrate in the mouth, offering improved bioavailability and patient compliance. Direct compression is a widely used manufacturing method due to its efficiency and cost-effectiveness. However, attaining an optimal balance between mechanical strength and rapid disintegration remains a challenge. Co-processed excipients (CPEs) enhance tablet properties by improving flowability, compressibility, and disintegration characteristics. This study investigates the effect of different CPEs on the wetting time and water absorption ratio of placebo ODTs produced by direct compression. Six series of placebo ODT, incorporating different CPEs (Hisorad™, Granfiller-D™, SmartEx®, Combilac®, Pearlitol® Flash, and Starlac®) were formulated. The wetting time and water absorption ratio, one of the disintegration performance indicators, were evaluated to determine the impact of CPE composition on ODT properties. The results showed that formulations containing Hisorad™ and Granfiller-D™ exhibited the shortest wetting times (25.07 ± 1.04 s and 14.14 ± 0.12 s, respectively) and the highest water absorption ratios (139.93% and 115.24%), suggesting superior disintegration characteristics. In contrast, Starlac® and Pearlitol® Flash demonstrated longer wetting times (24.14 ± 0.43 s and 21.99 ± 0.13 s) and lower absorption ratios (42.50% and 49.80%), which may be attributed to their composition and higher compression forces used during manufacturing. The conducted study highlight the importance of adequate CPE selection and compression force optimization in developing ODTs with desirable properties. Further pharmaceutical-technological characterization is necessary to fully assess the impact of these factors properties on the final formulation.