This chapter on Artificial Intelligence (AI) and the required workforce adaptation and skill development addresses the pressing global healthcare workforce shortage projected to reach 18 million by 2030, exacerbated by increasing lifespans and the accumulation of chronic conditions. It explores the potential of AI to revolutionise medical practice by improving efficiency, transforming clinical roles, and increasing productivity. It presents AI’s capabilities in diagnostics, treatment planning, and administrative tasks, illustrating its transformative potential. The discussion includes the current state of the medical workforce, highlighting significant shortages across various healthcare professions, and the impact of physician burnout on healthcare delivery. The chapter emphasises the need for adaptability in the medical field, underscoring the importance of interdisciplinary education and AI literacy integration into healthcare training. The chapter concludes by advocating for the incorporation of AI into medical curricula to prepare future healthcare professionals for the evolving landscape, ensuring they can harness AI’s benefits while maintaining the integrity of the doctor-patient relationship.