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Diagnosing community-acquired pneumonia (CAP) in patients with chronic heart failure (CHF) can be challenging. Oxidative stress (OS) plays an important role in the development of CAP and is involved in many cardiovascular diseases, including CHF. We aimed to evaluate the clinical and radiological features, as well as oxidative stress markers, in patients diagnosed with both CAP and CHF. In this study were included 210 patients and were categorized into two groups: Group 1 (n = 105) included patients with CAP and coexisting CHF, while Group 2 (n = 105) included patients with CAP without CHF. The age of patients in the study group ranged from 50 to 92 years, with a mean of 70.6 ± 8.89 years (95% CI [68.8–72.3]; Mn = 70.0; IQI = 11), with no significant differences between the groups. Worsening of dyspnea was observed in 98 patients (93.3%) in Group 1, significantly more than in Group 2, where it was reported in 73 patients (69.5%), (p < 0.0001). Bilateral pneumonia was slightly more frequent in Group 1 compared to Group 2—63 patients (60.0%) versus 57 patients (54.3%)—though the difference was not statistically significant, (p = 0.515). Pleural effusion was notably more common in Group 1, occurring in 41 patients (39.0%) compared to 14 patients (13.3%) in Group 2, (p < 0.0001). Additionally, total antioxidant activity (TAA), measured by the CUPRAC method, was significantly higher in Group 1 (6.70 ± 4.62) than in Group 2 (4.99 ± 4.29), (p = 0.006). These findings suggest that bilateral pneumonia, presence of pleural effusion, worsening of existing dyspnea, and elevated TAA values (CUPRAC method) may serve as valuable indicators for the early diagnosis of CAP in patients with CHF.

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Assessment of Oxidative Stress Related to Clinical and Imagistic Peculiarities in Hospitalized Patients with Community-Acquired Pneumonia and Chronic Heart Failure

  • 会议论文

  • 发表日期：

    2025年

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  • Virginia Cascaval,
  • Tatiana Dumitras,
  • Livi Grib,
  • Diana Fetco-Mereuta,
  • Sergiu Matcovschi,
  • Andrei Cealan,
  • Mariana Dumitras

摘要

Diagnosing community-acquired pneumonia (CAP) in patients with chronic heart failure (CHF) can be challenging. Oxidative stress (OS) plays an important role in the development of CAP and is involved in many cardiovascular diseases, including CHF. We aimed to evaluate the clinical and radiological features, as well as oxidative stress markers, in patients diagnosed with both CAP and CHF. In this study were included 210 patients and were categorized into two groups: Group 1 (n = 105) included patients with CAP and coexisting CHF, while Group 2 (n = 105) included patients with CAP without CHF. The age of patients in the study group ranged from 50 to 92 years, with a mean of 70.6 ± 8.89 years (95% CI [68.8–72.3]; Mn = 70.0; IQI = 11), with no significant differences between the groups. Worsening of dyspnea was observed in 98 patients (93.3%) in Group 1, significantly more than in Group 2, where it was reported in 73 patients (69.5%), (p < 0.0001). Bilateral pneumonia was slightly more frequent in Group 1 compared to Group 2—63 patients (60.0%) versus 57 patients (54.3%)—though the difference was not statistically significant, (p = 0.515). Pleural effusion was notably more common in Group 1, occurring in 41 patients (39.0%) compared to 14 patients (13.3%) in Group 2, (p < 0.0001). Additionally, total antioxidant activity (TAA), measured by the CUPRAC method, was significantly higher in Group 1 (6.70 ± 4.62) than in Group 2 (4.99 ± 4.29), (p = 0.006). These findings suggest that bilateral pneumonia, presence of pleural effusion, worsening of existing dyspnea, and elevated TAA values (CUPRAC method) may serve as valuable indicators for the early diagnosis of CAP in patients with CHF.