Overactive bladder (OAB) is characterized by the presence of lower urinary tract symptoms such as urgency, nocturia, daytime urinary frequency, with or without urge urinary incontinence. The prevalence of OAB is higher in women (33,7%) than in men (14,6%). Before considering invasive treatments, guidelines recommend urodynamics to identify DO. However, the clinical effectiveness of urodynamics has never been robustly assessed in women. We aimed to compare the clinical effectiveness of urodynamics at different ages of women with refractory OAB symptoms. In 72 patients with OAB enrolled in the study, data were collected through UDS. The patients were analyzed by age group – reproductive age (RP, n = 49) and climacteric period (CP, n = 27) and duration since the onset of the disease (≤6/ >6 months). In women with OAB in the CP, there was a general trend of lower mean values for urodynamic indices, with statistical significance for the following parameters: p < 0.001 – urinary index, strong urge to void; p < 0.01 – first sensation of void, water sample, estimated isovolumetric pressure – modified. In the group of women with OAB lasting >6 months after the onset of the disease, was established statistically significantly lower mean values for the urodynamic indices, which reveals a potential association between the more severe values of the paraclinical indices and longer duration since the onset of the disease. The results suggest that the urodynamic parameters are consistent and show differential associations with the age factor of women with OAB and the duration from disease onset factor.