The present study aimed the obtaining of some materials with potential applications in the development of cardiac patches. In this context, the developed hydrogels must present appropriate properties of myocardial tissue to ensure adequate compatibility and functionality. For their development, were involved synthetic polymers based on 2-hydroxyethyl methacrylate, acrylamide, bis-acrylamide, whose mechanical properties are higher compared to those of natural ones. Also, poly(N-isopropylacrylamide), a temperature-sensitive polymer, was used in order to obtain materials that exhibits improved bio adhesive properties at the contact with the human body (37 ℃, physiological conditions). In order to increase biocompatibility, fibrillar collagen was used as a natural polymeric filler. The aim of this study was to investigate the effects induced on materials by incorporating structurally modified gelatin, and oxidized alginate. The obtained materials were subsequently characterized to evaluate their biological fluids retention capacity, morphological characteristics, mechanical properties, bioadhesive properties, loading and controlated releasing efficiency of the active substance, cytocompatibility and biodegradability.