Chronic lower limb ulcers, especially those linked to diabetes mellitus, are serious complications arising from peripheral neuropathy, ischemia, and impaired wound healing. These lesions are among the primary causes of non-traumatic amputations and place a substantial burden on both patients and healthcare systems. Existing treatments are often invasive and associated with a high risk of complications, highlighting the need for effective, non-invasive alternatives that can be applied during early stages of the disease. This study presents the development of bioactive hydrogels composed of natural biopolymers (sodium alginate and xanthan gum) and propolis extract obtained from raw propolis, which was collected in the spring of 2024 from Apis mellifera hives. The hydrogels were designed as dressings for the treatment of diabetic foot ulcers and are aiming to maintain a moist, bioactive environment conducive to tissue regeneration while preventing bacterial infection and inflammation. Propolis, rich in flavonoids, phenolic acids, and terpenes, contributes to antimicrobial, anti-inflammatory, and immunomodulatory effects. These properties support wound healing and may reduce the progression of chronic lesions. By combining the structural benefits of biopolymers with the therapeutic action of propolis, the proposed formulations are offering a promising strategy for improving outcomes in chronic diabetic wound management. The three-dimensional structures with different composition ratios were assessed for morphology, fluid retention capacity, bioadhesive properties and cytocompatibility. The experimental results allowed us to consider the analyzed hydrogels as potential wound dressings for chronic diabetic ulcer.