Statistical Analysis of Combined Screening and Diagnostic Tests for Postpartum and Schizophrenia-Like Disorders
摘要
The Edinburgh Postnatal Depression Scale (EPDS) is widely used for diagnosing postpartum depression. However, there is a lack of specific tools for diagnosing postpartum psychosis. Common scales such as PANSS and BPRS are not adapted for diagnosing these conditions. The Postpartum Psychosis Evaluation Scale (PPES) is the only adapted tool for postpartum psychosis, with a sensitivity of 85.2% and specificity of 78.6%, but it is not widely used in global practice and requires further research. Due to this limitation, many specialists rely on combined diagnostic methods. This study conducted a statistical evaluation of combined diagnostic tests for postpartum disorders, including the following combinations: SCID/DSM-IV/EPDS, MINI/EPDS, EPDS/DSM-V/MINI, EPDS/DSM-V/SCID-V/BSI-53, BSI-18/GSI. Databases such as PubMed, MEDLINE, Scopus, Cochrane Library, and ResearchGate were searched. Articles containing data on sensitivity and specificity were selected in the sources found. Statistical analysis included correlation coefficients, normality tests, ANOVA, and covariance analysis. The analysis revealed a moderate negative correlation between the sensitivity and specificity of diagnostic tools. Combined tests, including EPDS, MINI, SCID, and BSI-18, improved both sensitivity and specificity. The area under the ROC curve (AUC) was 0.719, indicating moderate diagnostic accuracy. Combined diagnostic approaches are effective for diagnosing both postpartum depression and psychosis. However, there is a trade-off between sensitivity and specificity, making it essential to use multiple tools for optimal results. Further research is needed to enhance these methods in clinical practice.