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The aim of the study was to estimate the relationship between vitamin D3 (25(OH)D3) levels and oral cavity immunity parameters (secretory immunoglobulin A - sIgA, antimicrobial peptide LL-37 and transforming growth factor beta-1 (TGF-β1) in oral fluid in children with dental caries, for further development of non-invasive methods for prediction of DC.Were studied the levels of 25(OH)D3, sIgA, TGF- β1 LL-37 in oral fluid (OF) in a sample of 398 conventionally healthy children aged 3–15 years who were divided into two groups. The research group (L1) consisted of 132 children with carious lesions and 266 children without caries formed the control group (L0). The results obtained from clinical examination and DC prediction were confirmed by salivary biomarker complex study. In carioreceptive children, direct links were found between the OF content of 25(OH)D3 and the levels of LL-37 peptide, sIgA and TGF-β1, where was determined a lower level in children affected by dental caries. Conclusions: the combined assessment of 25(OH)D3, sIgA, TGF-β1 and LL-37 biomarkers in OF represents a non-invasive and innovative assay for DC prognosis with higher sensitivity and specificity and identification of subjects at increased risk of rapid, aggressive progression of the caries process. At the same time, for clinical use of OF biomarkers, it is necessary to develop standardized protocols and perform large studies in which the influence of different confounding variables is excluded.

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Level of Immunoregulatory Molecules and Vitamin D3 in Oral Fluid in Children with Carious Lesions

  • 会议论文

  • 发表日期：

    2025年

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  • Svetlana Plamadeala,
  • Elena Hristea,
  • Olga Bălteanu,
  • Olga Tagadiuc,
  • Aurelia Spinei,
  • Iurie Spinei

摘要

The aim of the study was to estimate the relationship between vitamin D3 (25(OH)D3) levels and oral cavity immunity parameters (secretory immunoglobulin A - sIgA, antimicrobial peptide LL-37 and transforming growth factor beta-1 (TGF-β1) in oral fluid in children with dental caries, for further development of non-invasive methods for prediction of DC.Were studied the levels of 25(OH)D3, sIgA, TGF- β1 LL-37 in oral fluid (OF) in a sample of 398 conventionally healthy children aged 3–15 years who were divided into two groups. The research group (L1) consisted of 132 children with carious lesions and 266 children without caries formed the control group (L0). The results obtained from clinical examination and DC prediction were confirmed by salivary biomarker complex study. In carioreceptive children, direct links were found between the OF content of 25(OH)D3 and the levels of LL-37 peptide, sIgA and TGF-β1, where was determined a lower level in children affected by dental caries. Conclusions: the combined assessment of 25(OH)D3, sIgA, TGF-β1 and LL-37 biomarkers in OF represents a non-invasive and innovative assay for DC prognosis with higher sensitivity and specificity and identification of subjects at increased risk of rapid, aggressive progression of the caries process. At the same time, for clinical use of OF biomarkers, it is necessary to develop standardized protocols and perform large studies in which the influence of different confounding variables is excluded.