Arterial Diameter Variation (ADV) signals have been used for a long time to assess arterial stiffness, their evolution with age and the morphology changes along gender, different conditions and pathologies. This paper describes the design, development, and characterization of a non-invasive system for acquiring ADV signals, intended for biomedical research applications. The project addresses a specific need for advancing non-invasive cardiovascular parameter studies. The developed system comprises a piezoelectric transducer integrated into a wristband and an acquisition unit featuring analog conditioning, high-resolution analog-to-digital conversion, and galvanic isolation. Accompanying software with a graphical user interface allows for system configuration, real-time signal visualization, and data logging. An automatic gain control system and digital filtering to reject 50 Hz power line noise were implemented to enhance signal quality. Experimental characterization of the piezoelectric transducers, specifically measuring the piezoelectric strain coefficient charge constant across the frequency range of interest, was performed to ensure their performance as dynamic pressure transducers. The system was validated through laboratory functional tests and successfully used in studies involving over 500 voluntary individuals, reliably recording ADV signals in all instances.