This study explores the implementation of health technologies (HTs) aimed at improving hand hygiene adherence and technique—critical factors in reducing healthcare-associated infections (HAIs). Based on a case study, it proposes a methodological approach to assess and compare available technologies in order to select those best suited to specific healthcare needs. The Biomedical Engineer is positioned as a key member of the healthcare team, responsible for leading technology evaluation and selection processes by integrating technical, clinical, economic, and contextual criteria. The analysis includes various HTs—such as electronic sensors, monitoring systems, visual alerts, and educational tools—evaluated for their impact, feasibility, acceptance, cost, and scalability. Electronic alert systems emerged as balanced solutions due to their effectiveness and ease of implementation, while more advanced alternatives, like video auditing and individual alcohol-based hand rub sensors, offer greater precision but involve higher complexity and resource requirements. This work presents a structured and practical approach that could be replicated or adapted in other healthcare settings. It highlights the importance of systematic needs assessment and structured comparison of alternatives—led by professionals such as Biomedical Engineers—as a valuable strategy for selecting technologies that are effective, sustainable, and context-appropriate for infection prevention and healthcare quality improvement