The increasing number of critically ill patients highlights the need for strategies to minimize the sequelae associated with admission to intensive care units (ICU) and the use of mechanical ventilation (MV). ICU hospitalization often involves multiple complications, including immobilization, mechanical ventilation, drug administration, and systemic inflammatory processes, which significantly impact patients’ quality of life, functionality, and level of dependency, even years after discharge. This work aims to analyze transvascular phrenic nerve stimulation and its implications for physiotherapy practice in the ICU. An exploratory literature search was conducted using the PubMed database, and articles related to this technique were found on the official Lungpacer website. A recent study involving patients with acute respiratory distress syndrome (ARDS) undergoing invasive MV and deep sedation suggests that phrenic nerve stimulation may restore communication between the brain, diaphragm, and lungs, which is often impaired by MV and sedation. Although further research is needed to confirm its effects on reducing cognitive decline and delirium, these preliminary findings are promising.