Hyperbaric medicine leverages the therapeutic benefits of hyperbaric oxygen therapy (HBOT), where patients breathe 100% oxygen at elevated atmospheric pressures within a hyperbaric chamber. This chapter introduces the physiological principles underlying HBOT and details its clinical applications in treating certain conditions such as carbon monoxide poisoning and decompression sickness. Emphasis is placed on safety protocols and risk mitigation strategies. Potential complications such as barotrauma, oxygen toxicity, and claustrophobia are addressed alongside best practices for emergency preparedness. A holistic approach to safety and operational rigor ensures the efficacy and reliability of HBOT in modern clinical settings.