Intracranial abscess is a rare condition. Prompt suspicion, diagnosis, and treatment are of paramount importance. Management involves a combination of antibiotic therapy and surgical intervention. They are the cornerstone of treatment and essential to prevent complications and minimize neurological damage associated. Diagnosis is based on symptoms, clinical history, microorganism isolation, and neuroimaging studies, last being crucial in early detection and orientation. Close monitoring and a multidisciplinary approach are essential in managing those cases. Controversial aspects of intracranial abscess management include the use of corticosteroids, antiepileptic agents, and hyperbaric oxygen therapy (HBOT) as an adjunctive treatment. While corticosteroids and antiepileptic therapy should be considered on a case-by-case basis, HBOT may offer potential benefits. Patient selection, timing, and protocols for HBOT initiation require further investigation but will be the focus. Overall, this chapter provides a comprehensive overview of the management of intracranial abscess and highlights areas of ongoing debate and research.