The goal of palliative care and rehabilitation in otorhinolaryngology is to improve the quality of life (QOL) of patients with limited life expectancy through a multidisciplinary approach. Patients with head and neck cancer (HNC), especially in the palliative situation, have a particularly high risk of life-threatening acute complications as well as a poor QOL. HNC resembles a chronic disease and is, therefore, one of the few types of cancer that require anticipatory treatment and long-term rehabilitation. Palliative care and rehabilitation in these patients include the evaluation of medical, physical, and psychosocial problems. The main medical problems affecting the QOL in these patients are eating and drinking disorders due to surgery and radiotherapy, communication problems due to laryngectomy or tracheostomy, edematous changes in the face and neck causing functional and cosmetic consequences, and ulcerated wounds with strong odor that often lead to social isolation. Rehabilitation during this period of life requires multidisciplinary work to ensure that individuals have maximum QOL at the end of their lives.