Performing artists, especially musicians, face unique physical, emotional, and psychological challenges due to the nature of their work. The demands of practice, performance, and constant striving for excellence often place them at a higher risk of developing physical injuries, mental health issues, and stress-related conditions. Additionally, the competitive nature of the arts, coupled with societal pressures, can amplify these challenges, leaving many performers vulnerable. This chapter delves into the concept of Performance Traumatic Stress Disorder (PTSD) as it applies to musicians. PTSD in this context encompasses both acute and chronic stressors that arise from performance-related experiences, injuries, and the occupational hazards of a career in the arts. The chapter provides a comprehensive framework for understanding and addressing these challenges by examining the principles of epidemiology, ergonomics, and epigenetics. The integration of neurobiological findings and practical interventions, including trauma-informed care and prevention strategies, underscores the importance of adopting a holistic approach to performer’s health. Patient-Reported and Performance-Related Outcomes (PROs) form the basis of developing a Practice-Based Evidence (PBE) approach that emphasizes the use of real-world data from the clinical setting to inform and improve patient care. This chapter aims to equip healthcare providers, educators, and performers with the knowledge and tools to foster resilience, enhance well-being, and ensure sustainable careers in the performing arts.