Decision makers play a crucial role in communicating information to the public to garner collectiveCoronavirus disease 2019 action in response to crises like the COVID-19COVID-19 pandemic, but face a critical knowledge gap on effective strategies for communicating scientific recommendations within vulnerable communities. This chapter discusses how decision makers communicated COVID-19COVID-19 information in the three lowest-income states in the United States (U.S.) Southeast: Alabama, Mississippi, and Louisiana. This study examined what COVID-19COVID-19 information was communicated to the public, how this information was communicated, and the successes and challenges experienced by decision makers. The study used semi-structured interviews of decision makers and thematic analyses. Data show that decision makers played diverse roles in disseminating information. Communication was tailored to local populations, and trusted local figures were used to enhance effectiveness. Institutional response varied, with coordination levels affecting communication success. Misinformation and public distrust presented significant challenges. Decision makers and the public experienced burnout due to the constant flow of information and evolving guidance. Our study suggests that, to improve future crisis communication, pre-crisis preparation is essential. This includes identifying and training communicators, clarifying communication channels, and targeting vulnerable populations. These steps will ensure effective communication of scientific information, promoting collective action and better public health outcomes.