Family violence-related mortality, particularly femicide, is a pressing global public health issue with profound implications for nursing practice. Each year, more than 45,000 women are murdered by intimate partners or family members, yet many cases go unreported. This chapter explores the scope, risk factors, and typologies of femicide, including intimate partner homicide, honour and dowry-related killings, and feminicide, which accounts for structural and state-sanctioned gendered violence. Special attention is given to the experiences of marginalized groups, including older women and sexual and gender minorities. The chapter highlights key risk factors for femicide, such as prior intimate partner violence, access to firearms, and patriarchal gender norms. Screening tools like the Danger Assessment, along with emerging artificial intelligence applications in healthcare, offer critical opportunities for early detection and intervention. Additionally, the chapter examines the broader impacts of femicide, including the intergenerational trauma experienced by children of victims and the psychological burden on communities. To combat femicide, nurses must engage in prevention strategies across individual, structural, and policy levels. Behavioural interventions, such as safety planning, alongside structural efforts like engaging men and boys in gender-equity programs, are essential. Furthermore, feminist advocacy remains pivotal in driving legal reforms and societal change. By integrating comprehensive assessment, interprofessional collaboration, and policy advocacy, nurses can play a central role in mitigating family violence-related mortality and advancing gender justice.