The impressive body of literature on gender transformation in the STEM sector is yet to translate into practice. While men continue to dominate the field, women are under-represented in both employment and leadership positions, globally. Whereas a growing body of intersectional leadership research focussing on the STEM sector exists, none of the located studies were conducted in Africa. This chapter seeks to contribute to the nascent body of intersectional leadership research in Africa, and in the STEM sector. Herein, we explore how the intersection of gender, age, national culture and industry culture impacts the lived experiences of women leaders in the Botswana STEM sector. The chapter draws on data from a doctoral research project that used constructivist grounded theory. The findings show that collusion between a patriarchal societal culture and a masculine industry culture created negative experiences for women, irrespective of age.