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The brain’s homeostatic constraints require it to operate optimally within narrow metabolic and physiological limits. When these limits are breached due to internal (genetics, adolescence, aging, reproduction) or external (environment, stress, trauma) factors, there are consequences. Applying the concepts developed in Chapter 3 , examples are presented that describe how infringement takes place and lead to pathophysiology. Allostatic changes in demand can overwhelm the brain’s energy systems and lead to symptom formation and abnormalities in information processing.

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Brain Energy Production Vulnerability and Pathophysiology

  • 章节

  • 出版模式：

    开放获取

  • 发表日期：

    2025年

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  • Caroline D. Rae,
  • L. Felipe Barros,
  • Alexander Behnke,
  • Manu S. Goyal,
  • Suzana Herculano-Houzel,
  • Daria Peleg-Raibstein,
  • Martin Picard,
  • Douglas Rothman,
  • Anthony C. Vernon,
  • Zoltan Sarnyai

摘要

The brain’s homeostatic constraints require it to operate optimally within narrow metabolic and physiological limits. When these limits are breached due to internal (genetics, adolescence, aging, reproduction) or external (environment, stress, trauma) factors, there are consequences. Applying the concepts developed in Chapter 3 , examples are presented that describe how infringement takes place and lead to pathophysiology. Allostatic changes in demand can overwhelm the brain’s energy systems and lead to symptom formation and abnormalities in information processing.