Through their respective inquiries, and each in their own way, Nishida Kitarō, Niels Bohr, and Yukawa Hideki questioned the foundational assumptions of Western metaphysics and classical physics. This chapter explores the shared philosophies and parallels among them, suggesting that their theoretical perspectives—while distinct—converge at critical junctures, particularly in their responses to and integration of scientific developments, especially those arising from quantum mechanics and quantum field theory. The synthesis they offer, combining the elements of Eastern philosophical traditions with cutting-edge Western scientific thought, provides a framework for a more comprehensive understanding of the complexity of reality and experience.