This chapter encompasses a discussion about the understanding of reproduction in the theory of autonomy, emphasizing the need to expand traditional theories of autonomous self-reproduction to account for interorganismal and ecological interactions. Drawing from recent contributions in the philosophy of biology, the chapter examines some of the limitations of self-reproduction as an endogenous process derived from self-production, highlighting cases such as sexual reproduction or symbiotic dependencies that illustrate the relational and interactive nature of reproduction. I then argue for an extended framework that integrates relational dependencies and distributed organizational processes.