This chapter examines the interconnected relationship of climate change, religion, health, and structural violence in the African context. It argues that although climate change has been associated with various weather challenges, including droughts, floods, heatwaves, and tropical cyclones, its effects have wider implications beyond the natural environment. In contemporary Africa, climate change has influenced how religion, health, and structural violence are perceived. By use of literature from Africa and beyond, the chapter introduces a new model/framework that captures the cause-and-effect relationship associated with climate change, religion, health, and structural violence. Analysis of existing secondary literature shows that there exists some form of linkage between climate change, religion, and health, thereby intensifying structural violence. This has an overall negative effect on development. This situation is more pronounced in rural communities that, apart from being prone to climate change shocks, have historically been marginalized. The chapter hence recommends that addressing climate change effects in Africa can potentially contribute toward development by mitigating health and structural violence challenges.