The Democratic Republic of the Congo (DRC) has faced numerous public health challenges, including recurrent outbreaks of the Ebola virus disease (EVD), monkey pox (mpox), and other epidemics. These experiences happen against a background of persistent war and conflict. Despite these challenges, the country has made significant strides in strengthening its public health infrastructure and capacity to respond to outbreaks. This chapter examines the role that religion has played in helping the country manage epidemic outbreaks, notably the Ebola crises, thus contributing to the achievement of United Nations Sustainable Development Goals (SDGs) 3, 5, and 6. The DRC has witnessed the significant involvement of religious institutions in fostering community resilience and promoting health-related SDGs at every turn of infectious disease outbreaks, be it Ebola, cholera, measles, etc. The chapter shows that the contribution of religious institutions to the fight against epidemics can be seen through the active involvement of religious leaders considered trusted messengers who promote public health messages received from the government; role of religious institutions in mobilizing people and providing resources through their vast network of hospitals, clinics, and healthcare personnel. The contribution of religious institutions in fighting against epidemics is also seen through psychological and spiritual support of individuals and affected communities. Religious leaders advocate for inclusive healthcare that addresses the specific needs of women, thus combatting some traditional biases against women and promoting some degree of gender equality. The chapter therefore concludes religious institutions are indispensable in the fight against epidemics in the DRC.