Biological systems minimise the long-term average prediction error of their sensory inputs, given their previously collected sensory data. When we conceive the brain as being a system that avoids the organism’s decay by regulation, the Free Energy Principle becomes more than just an answer to Schrödinger’s question on life but turns out to be a quantum leap in neuroscience research. The new perspective undermines classical models in cognitive science research and finds concrete realisations in predictive processing models. These models are powerful as they relate the unconscious with the conscious as exemplified by offering a case in which a psychological predicate is applicable to the brain in isolation without being prone to the mereological fallacy.