A careful medical history and a correct physical examination represent the first important step in the context of the first interview with the infertile couple. During this phase, a specific cause or any favoring factors may emerge that can help focus the subsequent diagnostic and therapeutic evaluations. Furthermore, in the pretreatment stage, a careful clinical assessment of the risk-benefit ratio is recommended, particularly concerning obstetric complications, potential neonatological relapses, and potential risks to the woman’s health. The accuracy and safety of screening and diagnostic programs have continuously improved since the introduction of prenatal testing. Similar to the screening tests currently in use, doctors and pregnant women may want to know and understand the most relevant features, benefits, and limitations of this new test, ideally before offering and undergoing the test, respectively. To achieve this, women attaining conception take active measures from easily available internet platforms rather than seeking help from healthcare professionals.