Women’s health care is mainly based on the model of biomedicine, which focuses on the diagnosis and treatment of diseases based on the understanding of the underlying pathophysiology. This approach is based on the concept that all patients have the same body, which is looked upon from outside, from what is called the “third-person perspective.” It necessarily excludes the patient as an individual person with feelings, thoughts, and behavior, which are so variable, multifold, and complex. The subjectivity of the patient (“first-person perspective”) is more of an unwanted noise. In practice, there are many situations in which we need to integrate both perspectives to provide good care. The spectrum reaches from patients with chronic diseases, unexplained and complex symptoms in whom the classical division between physical and mental health does not work, to issues of health behavior and prevention. There are different models that contribute to this integration. The saluto-genetic model and the life course approach contribute elements to the model of biopsychosocial health care for women. This chapter describes the principles and practice of this comprehensive, holistic care.