Female factors are involved in approximately 50% of infertility cases, and among them, ovulatory disorders represent one of the main causes, accounting for approximately 15% of infertility, but may be diagnosed in 33–40% of infertile women. Anovulatory infertility, according to the World Health Organization (WHO), is classified into three groups, based on gonadotropin and estrogen blood levels. The treatment of anovulatory infertility is based on ovulation induction, aiming at the selection of a single follicle and ultimately mono-ovulation. The aim of this chapter is to review the different treatment options for ovulation induction in patients with hypogonadotropic hypogonadism and PCOS.