There are multiple physiological changes in the 95-year old that generate a consensus of medication dosing that is safe and efficacious. There is a loss of body water, liver mass, and decreased blood flow to vital organs, which significantly affects drug metabolism. By age 80, one-half of the renal glomeruli are non-functional. Filtration slows not down to 1.l/min/year, which impacts the balance of sodium and free water. Sylvia presented to the Emergency Room with abdominal pain. A CT revealed infected diverticulitis that was treated with antibiotics. She was then challenged with C-difficile. She lost her resolve and went into a life-threatening depression.