The use of helmet-based interfaces in mechanical ventilation has evolved significantly beyond their initial applications in intensive care units (ICUs). Helmets are increasingly utilized in interventional procedures, offering advantages over traditional mask-based interfaces by reducing the risk of pressure ulcers, improving patient comfort, and enhancing procedural efficiency. Noninvasive ventilation (NIV) via helmets has proven effective in managing acute and chronic respiratory failure while preserving airway defenses and reducing the incidence of ventilator-associated complications. This study explores the clinical applications of helmet interfaces in interventional procedures, highlighting recent advancements in their design and functionality. Innovations such as barrier tents, which provide additional protection for healthcare workers during aerosol-generating procedures, are also examined. The integration of helmets into procedural workflows, particularly for bronchoscopy and other endoscopic interventions, has demonstrated improved patient stability and reduced the need for intubation. Further developments focus on optimizing helmet designs for specific medical scenarios, including pediatric care, anesthesia administration, and gastroscopy in infectious disease settings. Emerging technologies, such as neural signaling for synchronized ventilatory support, present opportunities for enhancing NIV effectiveness. However, challenges remain in minimizing dead space and improving procedural adaptability. Helmet-based ventilation is a promising alternative to conventional interfaces, offering enhanced safety, efficacy, and patient comfort. Ongoing research and design innovations will further expand the applications of helmet interfaces in various medical procedures, ensuring better outcomes for patients and healthcare providers.