As ventilation modes have advanced to improve patient synchronization, noninvasive ventilation (NIV) has become an option for managing both acute and chronic respiratory insufficiency, offering effective support while maintaining patient comfort. This chapter explores the key types of NIV modes, highlighting their mechanisms, clinical applications, and limitations. The discussion covers differences between volume-controlled and pressure-controlled ventilation, synchronization challenges, and essential parameters such as trigger, flow adjustments, and positive end-expiratory pressure (PEEP). Additionally, practical considerations such as unintentional leakage, humidification, oxygen delivery, and hemodynamic effects of NIV are reviewed. Understanding these aspects allows clinicians to select the most appropriate device and ventilation mode tailored to the patient’s condition, optimizing respiratory support while minimizing complications.