Continuous positive airway pressure (CPAP) and bilevel positive airway pressure (BIPAP) are two noninvasive positive-pressure ventilation (NIPV) techniques used in the treatment of various pulmonary conditions. CPAP is mainly indicated for patients with obstructive sleep apnea (OSA), while BIPAP is recommended for the treatment of diseases such as obesity hypoventilation syndrome and acute respiratory failure. Both CPAP and BiPAP require adjustment of various settings to optimize clinical efficacy and ensure patient compliance. The most important CPAP settings include pressure, ramp time, and humidity, while BiPAP involves tuning parameters such as inspiratory positive airway pressure (IPAP), expiratory positive airway pressure (EPAP), pressure support (PS), respiratory rate, fraction of inspired oxygen (FiO2), and inspiratory-to-expiratory ratio (I:E ratio). CPAP and BIPAP have been employed in interventional procedures to minimize complication rate. Flexible bronchoscopy (FOB) can benefit from both CPAP and BIPAP. They allow for a reduction of hypoxemia and subsequent respiratory complications. These NIPV techniques have also been utilized in other settings such as drug-induced sleep endoscopy, percutaneous endoscopic gastrostomy, and postoperative treatment.