Non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) is a non-invasive thyroid neoplasm with an indolent behavior. Cytology alone cannot definitively distinguish NIFTP from invasive encapsulated Follicular Variant Papillary Thyroid Carcinoma (EFVPTC). Diagnostic thyroid ultrasound cannot distinguish NIFTP from other types of thyroid cancer either. The diagnosis of NIFTP requires histologic assessment of a surgically resected nodule. For a diagnosis of NIFTP to be rendered, the tumor must meet strict criteria. Those criteria are (i) encapsulation or clear demarcation from the adjacent thyroid parenchyma; (ii) no capsular or vascular invasion; (iii) a nearly entirely follicular growth pattern (and no psammomatous calcifications); (iv) nuclear features of PTC; (v) <30% solid/insular/trabecular growth (vi) no cytoarchitectural features of other PTC subtypes (such as tall cell or columnar cell PTC); and (vii) no tumor necrosis or increased mitotic activity (mitoses number <3 per 2 mm2). Given the indolent nature of NIFTP, even in tumors >4 cm, thyroid lobectomy is a sufficient treatment in patients with NIFTP. There are no consensus guidelines regarding long-term follow-up of NIFTP; however, the most equivalent neoplasms close to NIFTP are thyroid neoplasms classified by the WHO as uncertain malignant potential, and it is reasonable to have a similar postoperative approach in these patients.