Here, zoocentric ethical frameworks will be discussed and their value for One Health will be analyzed. Ethical frameworks concerning animals have originated mostly from two fields, animal ethics, and the science of animal health and welfare. One could differ between two kinds of views on animals. One is on species similarities where those proponents focus on similarities between humans and other species. The other is on species differences, where proponents argue that one must consider species-specificness to avoid lumping all animals in the same bowl and acknowledging specific traits that might be as important as human traits. As an example of one of the first philosophers following this view, I briefly present Bernard Rollin, which gained influence in the scientific discussions of animal welfare. For One Health approaches, the latter position is more accurate and won’t hinder ascribing moral status to different species. This chapter’s in-depth analysis will be on Martha Nussbaum’s Capability Approach and David Fraser’s Four principles of animal ethics, which both have been proposed as fruitful within the One Health approaches.