The following work documents a methodology proposal for optimizing the blade of a Horizontal Axis Wind Turbine (HAWT) located in Baja California state in northwestern Mexico to enhance the total power output at the same inlet wind speed. For that matter, the employment of the solid–fluid interaction principle will allow us to know the effect of environmental conditions on the blade’s mechanical and energy performance. Likewise, this work includes a structural analysis of composite materials, used to verify that the blade can operate mechanically while generating energy. Thus, this paper will couple CFD software with a finite element program to simulate both the fluid structure interaction as well as the structural effects on the composite blade, alongside Blade Element Momentum (BEM) and other specialized wind turbine simulation software for the optimization process. Incidentally, the blade profiles considered for this paper must be included in the National Advisory Committee for Aeronautics (NACA) database as they are the most commonly used in the industry. Thus, this approach may be used as an aid for designing wind energy projects for small and medium businesses, by proposing solutions that result in higher power output while keeping the structural safety of the blade.