Patients experience significant pain even after laparoscopic cholecystectomy. The anterior abdominal wall above umbilicus is innervated by thoracic spinal nerves T7 to 10. The PROSPECT working group recommends a multimodal analgesia using a combination of opioids, non opioid analgesics and adjuvants for perioperative analgesia. In addition local infiltration at the incision is commonly used practise. Various regional blocks TAP block, rectus sheath block, intraperitonial LA instillation through laparoscopic port, thoracic Paravertebral block (TPVB), erector spinae block, thoracic epidural analgesia and quadratus lumborum block have been shown to be effective for cholecystectomy. We have described the possible regional analgesia strategies in patients undergoing cholecystetomy in this chapter.