To effectively mitigate seismic hazards and apply various strengthening methodologies aimed at improving the resilience of structures, it is essential to have data on their vulnerability to seismic effects. Without this information, it is impossible to implement adequate measures to enhance structural resilience. Additionally, the absence of such data prevents the provision of relevant information for disaster risk management. This paper examines the weakness of certain buildings located in Tuzla, the third most populated city in Bosnia and Herzegovina, which has experienced several nearby earthquakes. The most recent event occurred on February 10, 2022, at 3:17 P.M. local time, with a magnitude of 4.2, at a shallow depth of 10 km, approximately 20 km from Tuzla. A hybrid methodology was applied, combining analysis of design documentation, field investigations, and analytical methods. The key factors influencing structural vulnerability were site conditions, building age, construction system, construction materials, building height, and maintenance status. This study is a continuation of previous research on the vulnerability of structures in the Tuzla region. To enhance preparedness for seismic events, it is crucial to assess structural vulnerability, identify the most at-risk buildings, and conduct detailed numerical analyses to determine potential strengthening measures or recommendations for demolition where necessary.