This chapter examines the critical role of entrepreneurship in promoting sustainable development, with a focus on policies and strategies that align business practices with environmental, social, and economic objectives. In this context, sustainable entrepreneurship is defined in terms of the United Nations’ Sustainable Development Goals (SDGs), emphasizing the need to integrate sustainability into business models. Key themes covered in this chapter include green entrepreneurship, innovation, and social enterprises, all of which contribute to systemic change and the creation of continuous economic benefits. Additionally, digital infrastructure and regulatory frameworks are examined as fundamental factors in fostering an enabling environment for sustainable business practices. By analyzing policy measures that promote sustainable entrepreneurship, this chapter provides insights into how businesses can address global challenges while ensuring economic viability. Through case studies and practical applications, readers will gain a deeper understanding of the entrepreneurial role in developing sustainable solutions. This chapter will be particularly valuable for policymakers, entrepreneurs, and researchers seeking practical strategies to institutionalize sustainability within business frameworks.