Sustainable entrepreneurship is becoming a cornerstone of long-term success in today’s rapidly evolving corporate landscape, fostering creativity and ethical development through responsible growth. Emphasizing the harmony between social responsibility, environmental stewardship, and economic success, this chapter examines how entrepreneurial operations can utilize sustainable supply chain methods. Beginning with an introduction to an ecological supply chain, the book defines sustainability within an entrepreneurial context and emphasizes the need to align corporate activities with ethical resource management. We review fundamental management concepts, including strategic material acquisition, ethical labor practices, and the application of open and responsible procedures. The chapter examines how to incorporate sustainability into current business operations, the significant impact of technology on resource flow analysis and emissions reduction, and the benefits of forming close relationships. It also provides methods grounded in consistent key performance indicators and external audits to evaluate and explain its influence. Through real-world case studies and exemplary practices, the chapter presents pragmatic applications, challenges, and success stories, providing actionable insights and strategies for businesses striving for innovation and sustainable development in a competitive global market.