This chapter, Autonomy and Beneficence in Assisted Reproductive Technologies (ARTs), by Claudio S. Cinà discusses the ethical challenges of ART with regard to the principles of autonomy, beneficence, and justice. To balance societal needs with individual reproductive rights, it critically assesses genetic selection, transnational ART provision, and the rights of children born through ART. The chapter examines emerging technologies that are changing the nature of justice and equity, such as artificial wombs and preimplantation genetic testing that are enhanced by the availability of artificial intelligence. It also discusses such issues as structural injustice, cultural sensitivity, sustainability in the face of ARTs, and the psychological hardship children will be carrying because of ARTs. By incorporating international viewpoints, examples, and practical advice, it offers an ethical compass to enable health professionals to address present and future reproductive challenges. It raises awareness of the necessity to align societal expectations with individual requirements to facilitate equitable and inclusive reproductive health.