There has been increased utilization of minimally invasive surgery (MIS) in hepatopancreaticobiliary (HPB) surgery as it has proven to be safer, more efficient, and without compromise to oncologic outcomes. MIS also allows for improved visualization and magnification, optimal retraction, ease of dissection, and enhanced ergonomics. Furthermore, MIS hepatectomy has a favorable short-term outcome, including shorter length of hospitalization, less operative blood loss, less transfusion and analgesic requirements, faster return to oral intake, and fewer postoperative adhesions. Decreased intraoperative blood loss, which is likely due to improved visualization for hepatic inflow control, is of particular significance as it is one of the most dreaded complications of liver surgery and closely associated with increased morbidity and mortality. Long-term outcomes between MIS and open approaches are mostly equivalent, with no significant difference in overall survival or disease-free survival. Thus, MIS hepatectomy is associated with decreased surgical morbidity without compromising long-term and oncologic outcomes when compared to open hepatectomy. The MIS approach to hepatectomies is a safe and reasonable alternative when performed by an experienced surgeon.