Creating resilient infrastructure is of crucial importance to society, particularly in the face of escalating climate risks. As such, investments to increase resilience should be spent wisely to yield maximum benefits to transport users and society. However, decision-making regarding infrastructure dependencies is often based solely on qualitative information, which is inadequate for understanding the effectiveness of adaptation measures and the interconnectedness of infrastructure systems. This paper describes the Resilience Assessment and Adaptation for Critical infrastructurE (RA2CE) modeling framework. RA2CE aids infrastructure stakeholders in performing resilience assessments and to identify suitable adaptation options by generating comprehensive resilience maps for climate-induced events and ultimately pinpointing viable adaptation options. The need for systems-scale modeling, including interdependency analysis, demands fast, versatile, and generic models. We illustrate RA2CE’s ability to quantify damages, indirect losses, and cascading impacts, supporting long-term adaptation planning on regional and national scales. This approach ensures that investments in resilient transport planning are allocated wisely, maximizing benefits for transport users and society.