CEMBOX Digital Twin oriented Platform has been conceived to address the pressing needs in terms of design, maintenance, retrofitting and digitisation in the fields of infrastructure and mobility. The Platform’s Digital Twin is conceived as a real-time replica of the infrastructure that enables (i) the visualisation of assets in an interoperable BIM-GIS environment, (ii) the inspection of the state of infrastructure assets, integrating advanced inspection and monitoring technologies by means of IoT systems and other ICT enablers, and (iii) infrastructure condition analysis by means of Artificial Intelligence and advanced structural health monitoring algorithms, analysing the evolution of condition state over time, so as to support asset management decision-making. Following the needs of infrastructure asset inspection, maintenance, and management, CEMBOX has been orchestrated into four main services described in this article: Management, Inspection, Monitoring and Planning.