This chapter presents a comprehensive examination of cutting-edge research focused on the biomechanics of bone, cartilage, and biologics, specifically about the hand. The initial sections explore bone and cartilage, explaining how their microscopic structures and compositions shape their unique material properties. Exploring the intricate relationships between tissue microarchitecture and mechanical functionality can help us better understand how these tissues perform under various mechanical loads. This foundation sets the stage for a discussion on advanced methodologies employed in current research, including cadaveric studies that provide insights into real-world tissue behavior and finite-element modeling techniques that simulate mechanical responses in healthy and pathological conditions. Furthermore, the chapter thoroughly reviews biologics used in treating hand conditions, emphasizing their biomechanical implications. It scrutinizes innovative interventions, such as growth factors and stem cell therapies, highlighting how these biologics can enhance healing and repair mechanisms while considering biomechanics to optimize therapeutic outcomes. Through this integrated approach, the chapter aims to illuminate the complexities of hand biomechanics and the promising future of biological applications in orthopedic practice.